Hugh Jackman

Gabriel Van Helsing (voice)

Robbie Coltrane

Mr. Hyde (voice)

David Wenham

Carl (voice)

Grey DeLisle

First Victim (voice)

Dwight Schultz

Dr. Jekyll (voice)

John DiMaggio

Coachman (voice)

Scott Mosenson

Palastwache (voice)

Alun Armstrong

Cardinal Jinetta (voice)

Roger L. Jackson

Gentleman (voice)

Julia Fletcher

Lady (voice)

Tress MacNeille

Queen Victoria (voice)

Tara Strong

Young Victoria (voice)

James Arnold Taylor

Narrator (voice)