Christine Cavanaugh

Charles 'Chuckie' Finster Jr. (voice)

Cheryl Chase

Angelica C. Pickles (voice)

Kath Soucie

Phillip 'Phil' DeVille/Lillian 'Lil' DeVille/Elizabeth 'Betty' DeVille (voice)

Tara Strong

Dylan Prescott 'Dil' Pickles (voice)

Cree Summer

Susan 'Susie' Carmichael (voice)

Tress MacNeille

Charlotte C. Pickles (voice)

Melanie Chartoff

Didi Pickles (voice)

Jack Riley

Stu Pickles (voice)

Joe Alaskey

Louis 'Grandpa' Pickles (voice)

Michael Bell

Drew Pickles/Charles 'Chaz' Finster, Sr. (voice)

Charlie Adler

Professor Spooky (voice)

E. G. Daily

Tommy Pickles (voice)