David Mattey

Toxic Avenger / Noxious Offender

Debbie Rochon

Ms. Weiner

Clyde Lewis

Toxie (voice)

Heidi Sjursen

Sarah / Claire

Ron Jeremy

Mayor Goldberg

Tom Fulp

Painter

Paul Kyrmse

Sgt. Kabukiman / Evil Kabukiman

Stan Lee

Prologue / Epilogue Narrator

Joe Fleishaker

Chester / Lardass

Dan Snow

Sgt. Kazinski

Michael Budinger

Tito

Lisa Terezakis

Sweetie Honey

Barry Brisco

Pompey

Corey Feldman

Sarah's Gynecologist

Trent Haaga

Tex Diaper

Mark Torgl

Evil Melvin

Rick Collins

Amortville Police Chief

Mitch Cohen

Lucifer

Lisa Gaye

Abortion Counselor

James Gunn

Dr. Flem Hocking

Al Goldstein

Press Secretary

Taylor Mead

Award Presenter

Yaniv Sharon

Rex Diaper

Will Keenan

Man Hit by Car

Melissa Bacelar

Dr. Hocking's Nurse

Jasi Cotton Lanier

Wet Lesbian

Lemmy Kilmister

Good Lemmy / Bad Lemmy

Julie Strain

Herself (Facelift Death)

Kevin Eastman

Himself (Breast Smoosh Death)

Tiffany Shepis

Beautiful Interpretative Dancer

Eli Roth

Beautiful Young Boy

Hugh Hefner

President of the United States

Charlotte Kaufman

Tromaville / Amortville Citizen

Lloyd Kaufman

Man in Public Service Announcement

Neriah Davis

Glamorous Gyno-American

Devin DeVasquez

Glamorous Gyno-American

Taimie Hannum

Glamorous Gyno-American

Masuimi Max

Glamorous Gyno-American

Doria Rone

Glamorous Gyno-American

Petra Verkaik

Glamorous Gyno-American

Hank the Angry Drunken Dwarf

God

Celeste Octavia

Glamorous Gyno-American / Naked Nurse (as Celeste Octavian)

Tromelissa Saytar

Lesbian Art Student

Terri Firmer

Wet Lesbian / Topless Deaf Translator

Bella Compagna

Diaper Mafia Temptress

Brandi Brandt

Glamorous Gyno-American

Randy Sklar

Randy Diaz

Jason Sklar

Jason Gonzalez