Glenn Close

Dr. Elaine Keener (segments "This is Dr. Keener" and "Fantasies about Rebecca")

Calista Flockhart

Christine Taylor (segments "Goodnight Lilly, Goodnight Christine" and "This is Dr. Keener")

Holly Hunter

Rebecca Waynon (segment "Fantasies About Rebecca")

Cameron Diaz

Carol Faber (segment "Love Waits For Kathy")

Kathy Baker

Rose (segments "Someone For Rose" and "Fantasies about Rebecca")

Amy Brenneman

Detective Kathy Faber (segment "Love Waits For Kathy")

Gregory Hines

Robert (segment "Fantasies About Rebecca")

Valeria Golino

Lilly (segment "Goodnight Lilly, Goodnight Christine")

Matt Craven

Walter (segments "Fantasies About Rebecca" and "Love Waits For Kathy")

Miguel Sandoval

Sam (segment "Love Waits For Kathy")

Roma Maffia

Debbie (segments "Fantasies About Rebecca" and "Love Waits For Kathy")

Penelope Allen

Nancy (segment "Fantasies About Rebecca")

Noah Fleiss

Jay (segment "Someone For Rose")

Danny Woodburn

Albert (segments "Someone For Rose" and "Love Waits For Kathy")

Irma St. Paule

Elaine's Mother (segment "This is Dr. Keener")

Laura Leigh Hughes

Receptionist (segment "Fantasies About Rebecca")

Elpidia Carrillo

Carmen Alba

Mika Boorem

June (segments "Love Waits For Kathy" and "Goodnight Lilly, Goodnight Christine")

Juanita Jennings

Erik King