Scott Wolf

Scamp (speaking) (voice)

Alyssa Milano

Angel (speaking) (voice)

Chazz Palminteri

Buster (speaking) (voice)

Jeff Bennett

Tramp / Jock / Trusty / Dogcatcher (voice)

Jodi Benson

Lady (voice)

Bill Fagerbakke

Mooch (voice)

Mickey Rooney

Sparky (voice)

Bronson Pinchot

Francois (voice)

Cathy Moriarty

Ruby (voice)

Mary Kay Bergman

Si (voice)

Debi Derryberry

Annette (voice)

Barbara Goodson

Darling (voice)

Nick Jameson

Jim Dear (voice)

Tress MacNeille

Aunt Sarah / Am (voice)

Rob Paulsen

Otis (voice)

Kath Soucie

Collette / Danielle (voice)

Frank Welker

Reggie (voice)

April Winchell

Mrs. Mahoney (voice)

Jim Cummings

Tony (voice)

Michael Gough

Joe (voice)

Jess Harnell

Buster (singing voice) (uncredited)

Andrew McDonough

Junior (voice)