Kate Higgins

Frankie Stein / Lilith Van Helscream (voice)

Cindy Robinson

Jackson Jekyll / Holt Hyde / Operetta / Additional Voice (voice)

Salli Saffioti

Clawdeen Wolf / Cleo de Nile (voice)

Erin Fitzgerald

Abbey Bominable / C.A. Cupid / Clair / Additional Voices (voice)

Laura Bailey

Lagoona Blue / Headmistress Bloodgood (voice)

Debi Derryberry

Draculaura (voice)

Ogie Banks

Clawd Wolf (voice)

Evan Smith

Deuce Gorgon / Gil Webber / Thad (voice)

America Young

Howleen Wolf / Toralei Stripe (voice)

Audu Paden

Ghoulia Yelps / Manny Taur / Sheriff / Additional voices (voice)

Cam Clarke

Heath Burns / Mr. Rotter / Goon #2 (voice)

Julie Maddalena

Robecca Steam / Venus McFlytrap (voice)

Steve Staley

Chad / Kid #1 (voice)

Mark Mercado

Gargoyle (voice)

Ira Singerman

Goon #1 (voice)

Andrew Duncan

Narrator (voice)

Wendee Lee

Nefera De Nile (voice) (uncredited)

Jonathan Lipow

Tiki People (voice) (uncredited)